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Milind Phadnis, PhD

Research Assistant Professor, Department of Biostatistics
Member of Drug Discovery, Delivery & Experimental Therapeutics, The University of Kansas Cancer Center
Primary office:
(913) 945-7986


B.E., Production Engineering, Mumbai University, Mumbai, India
M.S., Industrial Engineering, University of Alabama, Tuscaloosa, AL
Ph.D., Biostatistics, University of Alabama at Birmingham, Birmingham, AL

Personal Mission Statement

My mission is to be able to deploy my statistical training and skill sets to positively impact public health. One of my contributions in health services research has resulted in a novel method of analysis for estimating the effectiveness of a variety of cardio-protective medications in the chronic dialysis population. One of the significant findings of this research is that the effectiveness of these medications is affected by the myriad time-dependent patterns of drug usage as opposed to the standard methods that looked only at use versus non-use. Another of my contributions in this area has been to statistically model the effect of various risk factors on ischemic and hemorrhagic strokes. One of the potential public health impacts of my research is the ability to estimate the residual longevity of those patients who experience a stroke. I have also been able to translate my knowledge of advanced methods in Survival Analysis to the domain of clinical trials in neurology. In the near future I wish to expand my expertise in the area of clinical trials in cancer so as to be able to make significant contributions toward cancer research.

 

Research

Research Focus

My statistical methodological interests include Time-to-event data analyses in the modeling of public outcomes related health care data, clinical trials, and study of disease progression. My collaborations have been in the field of gastroenterology, pharmacoepidemiology, neurology, smoking cessation and other related fields. Recently, I have started collaborating with researchers in Phase-I investigator initiated trials in cancer.

Selected Publications

1. Mel Wilcox C, Martin T, Phadnis M, Mohnen J, Worthington J, Hirschowitz B. Absence of gastrointestinal infections in a cohort of patients with Zollinger-Ellison syndrome and other acid hypersecretors receiving long-term acid suppression with lansoprazole. (2008) BMC Gastroenterology. Vol. 8: 18-21 doi: 10.1186/1471-230X-8-18 PMID: 18507843; PMCID: PMC2414526

2. Phadnis MA, Elam ME. A methodology to improve PCI use in industry. (2008)  Journal of Modern Applied Statistical Methods. Vol. 7(2): 588-596

3. Mel Wilcox C, Phadnis M, Varadarajulu S. Biliary stent placement is associated with post ERCP pancreatitis. (2010) Gastrointestinal Endoscopy. Vol. 72(3): 546-550. doi: 10.1016/j.gie.2010.05.001 PMID: 20633882

4. Decker C, Christein JD, Phadnis MA, Mel Wilcox C, Varadarajulu S. Biliary metal stents are superior to plastic stents for preoperative biliary decomposition in pancreatic cancer. (2011) Surgical Endoscopy. Vol. 25(7): 2364-2367. doi: 10.1007/s00464-010-1552-6 PMID: 21373939; PMCID: PMC3116134

5. Varadarajulu S, Bang JY, Phadnis MA, Christein JD, Mel Wilcox C. Endoscopic transmural drainage of peripancreatic fluid collections: Outcomes and predictors of treatment success in 211 consecutive patients. (2011) Journal of Gastrointestinal Surgery. Vol. 15(11): 2080-2088. doi: 10.1007/s11605-011-1621-8 PMID: 21786063

6. Varadarajulu S, Phadnis MA, Christein JD, Mel Wilcox C. Multiple transluminal gateway technique for EUS-guided drainage of symptomatic walled-off pancreatic necrosis. (2011) Gastrointestinal Endoscopy. Vol. 74(1): 74-80. doi: 10.1007/s00464-010-1552-6 PMID: 21612778

7. Varadarajulu S, Wilcox CM, Latif SU, Phadnis M, Christein JD. Management of pancreatic fluid collections (PFCs): A changing of the guard from surgery to endoscopy. (2011) The American Surgeon. Vol. 77(12): 1650-1655. PMID: 22273224

8. Ranney NR, Phadnis M, Trevino J, Ramesh J, Wilcox CM,  Varadarajulu S. Impact of biliary stents on EUS-guided FNA of pancreatic mass lesions. (2012) Gastrointestinal Endoscopy. Vol. 76(1): 76-83. doi: 10.1016/j.gie.2012.02.049 PMID: 22726468; PMCID: PMC4163947

9. Azih LC, Broussard BL, Phadnis MA, Heslin MJ, Eloubeidi MA, Varadarajulu S, Arnoletti JP. Endoscopic ultrasound evaluation in the surgical treatment of duodenal and peri-ampullary adenomas. (2013) World Journal of Gastroenterology. Vol. 19(4): 511-515. doi: 10.3748/ wjg.v19.i4.511 PMID: 23382629; PMCID: PMC3558574

10. Wetmore JB, Ellerbeck EF, Mahnken JD, Phadnis M, Rigler SK, Mukhopadhyay P, Spertus JA, Zhou X, Hou Q, Shireman TI. Atrial fibrillation and risk of stroke in dialysis patients. (2013) Annals of Epidemiology. Vol. 23(3): 112-118. doi: 10.1016/j.annepidem.2012.12.011 PMID: 23332588; PMCID: PMC3570646           

11. Wetmore JB, Ellerbeck EF, Mahnken JD, Phadnis MA, Rigler SK, Spertus JA, Zhou X, Mukhopadhyay P, Shireman TI. Stroke and the ‘stroke belt’ in dialysis: contribution of patient characteristics to ischemic stroke rate and its geographic variation. (2013) Journal of the American Society of Nephrology. Vol. 24(12): 2053-2061. doi: 10.1681/ASN.2012111077 PMID: 23990675; PMCID: PMC3839545

12. Wetmore JB, Phadnis MA, Mahnken JD, Ellerbeck EF, Rigler SK, Zhou X, Shireman TI. Race, ethnicity, and state-by-state geographic variation in hemorrhagic stroke in dialysis patients. (2014) Clinical Journal of the American Society of Nephrology. Vol. 9(4): 756-763. doi: 10.2215/ CJN.06980713 PMID: 24458073; PMCID: PMC3974358

13. Phadnis MA, Shireman TI, Wetmore JB, Rigler SK, Zhou X, Spertus JA, Ellerbeck EF, Mahnken JD. Estimation of drug effectiveness by modeling three time-dependent covariates: An application to data on cardioprotective medications in the chronic dialysis population. (2014) Statistics in Biopharmaceutical Research. Vol. 6(3): 229-240. doi: 10.1080/19466315.2014.920275

14. Shireman TI, Phadnis MA, Wetmore JB, Zhou X, Rigler SK, Spertus JA, Ellerbeck EF, Mahnken JD. Antihypertensive medication exposure and cardiovascular outcomes in hemodialysis patients. (2014) American Journal of Nephrology. Vol. 40(2): 113-122. doi: 10.1159/000365255 PMID: 25139551; PMCID: PMC4175183

15. Wetmore JB, Phadnis MA, Ellerbeck EF, Shireman TI, Rigler SK, Mahnken JD. Relationship between stroke and mortality in dialysis patients. (2015) Clinical Journal of the American Society of Nephrology.  Vol. 10(1): 80-89. doi: 10.2215/CJN.02900314 PMID: 25318759; PMCID: PMC4284406